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class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海臨辰醫(yī)藥科技有限公司</a></p><p><span>聯(lián)系人：</span>葉海岑</p><p><span>郵箱: </span>info@linchenpharm.com</p><p><span>電話: </span>13761181955</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-31606595</p><p><span>地址: </span>辰花路5088弄221號</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="zjldvmj" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="bq3pm33" class="box"><p><p> 化學(xué)酶法合成D-泛解酸內(nèi)酯 </p> <p> 泛酸具有一個(gè)手性中心，其中D-泛酸是工業(yè)生產(chǎn)所需要的。化學(xué)法合成D-泛酸（或泛酸鈣）工藝成熟，但步驟繁瑣且對消旋化產(chǎn)物進(jìn)行結(jié)晶拆分費(fèi)用昂貴。利用生物酶法生產(chǎn)光學(xué)純的D-泛酸可進(jìn)一步升級合成工藝，提升產(chǎn)品的競爭力。生物酶法主要包括利用生物菌體發(fā)酵生產(chǎn)和酶法催化。生物菌體發(fā)酵法利用基因工程技術(shù)在大腸桿菌、谷氨酸棒狀桿菌、枯草芽孢桿菌和釀酒酵母等宿主菌中表達(dá)泛酸生物合成基因和氨基酸生物合成基因，并利用基因工程菌進(jìn)行微生物發(fā)酵，泛酸產(chǎn)量較高，D-泛酸鈣泛解酸內(nèi)酯商家，但微生物發(fā)酵法發(fā)酵液成分復(fù)雜，后續(xù)的產(chǎn)物分離提取較困難。酶法催化可以替代化學(xué)反應(yīng)過程中的某些步驟，以化學(xué)酶法的方式來實(shí)現(xiàn)D-泛酸的前體物質(zhì)D-泛酸內(nèi)酯的生產(chǎn)。目前國內(nèi)外酶法催化生產(chǎn)D-泛解酸內(nèi)酯的方法主要包括酶法選擇性拆分和酶法不對稱合成。關(guān)于酶法不對稱合成，D-泛酸鈣泛解酸內(nèi)酯商家，筆者主要綜述了三種路線：1）前手性物質(zhì)酮泛解酸或酮泛解酸內(nèi)酯不對稱還原成D-泛解酸內(nèi)酯；2）利用(R)-羥基腈裂合酶來合成泛解酸內(nèi)酯前體羥基特戊醛；3）醇脫氫酶參與的化學(xué)酶法合成D-泛解酸內(nèi)酯，D-泛酸鈣泛解酸內(nèi)酯商家。 </p> <p> <br /> DL泛解酸內(nèi)酯誘導(dǎo)拆分新技術(shù)。此**技術(shù)制備D-泛酸鈣具有很強(qiáng)成本競爭優(yōu)勢！D-泛酸鈣泛解酸內(nèi)酯商家</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="D-泛酸鈣泛解酸內(nèi)酯商家,泛解酸內(nèi)酯" src="https://tyunfile.71360.com/WaterMark/UploadFile//637280289746210938/9268872.png"></div><p> D-泛酸鈣，化學(xué)名為N-(α,γ-二羥基-β,β-二甲基丁酰)-β-氨基丙酸鈣，俗稱維生素B5，是輔酶A的組成部分，它是人體和動(dòng)物維持正常生理機(jī)能不可缺少的物質(zhì)，廣泛應(yīng)用于飼料、醫(yī)藥、食品等工業(yè)。 </p> <p> D-泛醇，俗稱維生素原B5，是一種優(yōu)異的皮膚與頭發(fā)保護(hù)劑，可使皮膚保持柔嫩、毛發(fā)光亮油潤，廣泛應(yīng)用在護(hù)發(fā)產(chǎn)品和化妝品中，還可用于醫(yī)藥、保健食品等領(lǐng)域。 </p> <p> D-泛酸鈣的制備方法主要有以下兩種。 </p> <p> 一種是先化學(xué)合成DL-泛酸鈣，通過拆分DL-泛酸鈣而制得D-泛酸鈣。 </p> <p> 另一種是通過化學(xué)法或生物法拆分關(guān)鍵中間體DL-泛解酸內(nèi)酯得到D-泛解酸內(nèi)酯，再由D-泛解酸內(nèi)酯與β--氨基丙酸反應(yīng)合成D-泛酸鈣。 </p> <p> D-泛醇由D-泛解酸內(nèi)酯與β--氨基丙醇反應(yīng)制得。 </p> <p> <br /> 98以上泛解酸內(nèi)酯中文別名:D-泛酰內(nèi)酯。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="D-泛酸鈣泛解酸內(nèi)酯商家,泛解酸內(nèi)酯" src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637278338760781250/415124.png"></div><p style="text-indent:25px">CAS: 137-08-6分子式: C18H32CaN2O10分子量: 476.54中文名稱: 右旋泛酸鈣(R)-N-(2,4-二羥基-3,3-二甲基-1-氧代丁基)-β-丙氨酸鈣(2:1)D-泛酸鈣泛酸鈣本多生酸鈣N-(2,4-二羥基-3,3-二甲基丁酰)-β-氨基丙酸鈣維生素B5標(biāo)準(zhǔn)品英文名稱: Calcium D-pantothenateN-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, calcium salt (2:1), (R)-.beta.-AlaninePantholincalcium salt (2:1), (+)-pantothenic acibeta-alanine, n-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, calcium salt (2:1),( theta)-(+)-pantothenic acid calcium saltcalcium d(+)-n-(alpha,gamma-dihydroxy-beta,beta-dimethylbutyryl)-beta-alaninacalcium panthothenatecalcium pantothenatecalpanated-calcium pantothenatedextro calcium pantothenaten-(2,4-dihydroxy-3,3-dimethylbutyryl)-beta-alanine calcium</p><p style="text-indent:25px">一種微生物新菌株內(nèi)生***HL-02 (PlectospHaereella cucumerina HL-2)及其在微生物轉(zhuǎn)化制備D-泛解酸內(nèi)酯中的應(yīng)用，所述的應(yīng)用以DL-泛解酸內(nèi)酯為底物，以內(nèi)生*** HL-2發(fā)酵所得菌液或菌液制備的初酶液為酶源，20～45℃下，在含有氯化鈣的Tris-HCl緩沖溶液的反應(yīng)體系中進(jìn)行水解反應(yīng)得水解液，取水解液用乙酸乙酯進(jìn)行酯化反應(yīng)，反應(yīng)液經(jīng)后處理制得D-泛解酸內(nèi) 酯；本發(fā)明提供了一株新的可產(chǎn)D-泛解酸內(nèi)酯水解酶的微生物菌種內(nèi)生***HL-2，該菌種應(yīng)用于拆分DL-泛解酸內(nèi)酯，立體選擇性好，反應(yīng)條件溫和。D-泛解酸內(nèi)酯主要用于D-泛酸鈣和D-泛醇的合成。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="D-泛酸鈣泛解酸內(nèi)酯商家,泛解酸內(nèi)酯" src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637278336147089843/7803549.png"></div><p> 泛酸鈣大量用于飼料工業(yè)。 </p> <p> 泛酸鈣作為維生素飼料添加劑，畜禽養(yǎng)殖中具有重要的作用。 </p> <p> 泛解酸內(nèi)酯加工后生成 D-泛解酸內(nèi)酯（左酯）。 </p> <p> 氫氰酸作為泛酸系列的關(guān)鍵中間體D-泛解酸內(nèi)酯的重要原料。 </p> <p> D-泛酸存在于植物以及低等生物的代謝過程中，被稱為遍多酸或本多酸，是水溶性維生素B族的一種。 </p> <p> 微生物酶法拆分泛酸鈣合成中間體泛解酸內(nèi)酯的方法。 </p> <p> <br /> </p> <p> 用微生物酶將 D, L-泛解酸內(nèi)酯拆分得到 D-泛解酸內(nèi)酯，與 B再一丙氨酸鈣縮合生產(chǎn) D-泛酸鈣。 </p> <p> <br /> D-泛解酸內(nèi)酯是一種重要的原料藥中間體。D-泛解酸內(nèi)酯合成</p> D-泛酸鈣世界市場年消費(fèi)量約30000噸。<p style="text-indent:25px">作為腦代謝的D-泛解酸內(nèi)酯，主要用于生產(chǎn)泛酸鈣。D-泛酸鈣泛解酸內(nèi)酯商家</p><p> 微生物選擇性的不對稱水解DL-泛解酸內(nèi)酯中的D-泛解酸內(nèi)酯，得到D-泛解酸，再將D-泛解酸進(jìn)行內(nèi)酯化生產(chǎn)D-泛解酸內(nèi)酯。該方法工藝控制簡單，微生物酶專一性好，可以得到高光學(xué)純度的D-泛解酸內(nèi)酯。 </p> <p> <br /> </p> <p> <br /> </p> <p> <br /> </p> <p> 利用D-泛解酸內(nèi)酯水解酶N末端序列,并根據(jù)NCBI中公布的D-泛解酸內(nèi)酯水解酶cDNA序列設(shè)計(jì)了一個(gè)特異引物,該引物結(jié)合Oligo(dT)15,以串珠鐮孢霉(Fusarium moniliforme)CGMCC 0536 mRNA反轉(zhuǎn)錄得到的總cDNA為模板進(jìn)行擴(kuò)增,獲得約1.5kb左右的片段,將其克隆到T載體上進(jìn)行測序,對測得的序列進(jìn)行分析,重新設(shè)計(jì)了一對引物,并在引物兩端分別加上限制酶EcoRI和SalI的識別位點(diǎn)序列,利用熱啟動(dòng)PCR成功地?cái)U(kuò)增出了D-泛解酸內(nèi)酯水解酶基因, D-泛酸鈣泛解酸內(nèi)酯商家</p><p style="text-indent:25px">上海臨辰醫(yī)藥科技有限公司坐落辰花路5088弄221號，交通便利，環(huán)境優(yōu)美，是一家貿(mào)易型企業(yè)。公司致力于為客戶提供安全、質(zhì)量有保障的質(zhì)量產(chǎn)品及服務(wù)，是一家私營有限責(zé)任公司企業(yè)。公司業(yè)務(wù)涵蓋[ "泛解酸內(nèi)酯", "有機(jī)可可粉有機(jī)果粉", "阿拉伯膠瓜爾膠 ", "BIS TRIS " ]，價(jià)格合理，品質(zhì)有保證，深受廣大客戶的歡迎。上海臨辰醫(yī)藥以創(chuàng)造***產(chǎn)品及服務(wù)的理念，打造高指標(biāo)的服務(wù)，引導(dǎo)行業(yè)的發(fā)展。</p></p><br /><p>文章來源地址: 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