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onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="q7uw8sh" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>江蘇好的大分子生物分析平臺,大分子生物分析平臺</p><p><span>***更新：</span>2021-01-12 06:08:36</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="84tqifh" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">寧波熙寧檢測技術(shù)有限公司</a></p><p><span>聯(lián)系人：</span>王蒙</p><p><span>郵箱: </span>meng.wang@accurantbio.com</p><p><span>電話: </span>13585708897</p><p><span>傳真: </span>0574_</p><p><span>網(wǎng)址: </span>https://www.accurantbio.com</p><p><span>手機: </span>0574-87878487</p><p><span>地址: </span>浙江省寧波市鄞州區(qū)聚賢路587弄A5幢4樓</p><p>[當前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="ptgamol" class="page-proshow02"><p class="title">詳細說明</p><div id="fuwlcmx" class="box"><p><p> 生物類似藥研發(fā)期間需要對生物類似藥和原研藥的PK進行頭對頭的比較。在進入驗證階段之前，應仔細解讀方法開發(fā)過程中獲得的數(shù)據(jù)。 </p> <p> 在選擇檢測平臺時，首先要考慮待測藥物的固有性質(zhì)和分子特點（例如，藥物與其靶點之間特定的相互作用，以及在特定生物基質(zhì)中與可溶性受體和膜結(jié)合受體的復合物的產(chǎn)生情況）。其他參數(shù)如內(nèi)源性的藥物存在、基質(zhì)中的抗藥抗體、檢測靈敏度、檢測的動態(tài)范圍以及可使用的樣本量都應考慮在內(nèi)。 </p> <p> 考慮到藥物開發(fā)的過程很長，臨床試驗的跨度長達數(shù)年，選擇一個相對穩(wěn)定的實驗平臺進行藥物的檢測就顯得至關(guān)重要，江蘇好的大分子生物分析平臺。熙寧生物專注于大分子生物檢測，江蘇好的大分子生物分析平臺。生物標志物(Biomarker)受體占位(RO)，江蘇好的大分子生物分析平臺，以及基于流式細胞術(shù)(FACS)，精翰生物專注于臨床大分子檢測。江蘇好的大分子生物分析平臺</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇好的大分子生物分析平臺,大分子生物分析平臺" src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413936533023111/2485964.png"></div><p style="text-indent:25px">色譜和質(zhì)譜技術(shù)在醫(yī)藥研究中扮演著越來越重要的角色，從早期研發(fā)、表征分析、工藝優(yōu)化到CMC、QC分析均有應用。熙寧生物，致力于更好的生物質(zhì)譜檢測技術(shù)開發(fā)與應用，從組學全覆蓋研究到單分子深入分析，逐步聚焦，只為實現(xiàn)更好的生物質(zhì)譜應用；從科技服務(wù)到醫(yī)藥研究，打通機制研究到臨床應用的全通路。熙寧生物以生物科技成就他人、造福大眾。圖1質(zhì)譜在科技服務(wù)和生物醫(yī)藥中的應用我們所提供的的服務(wù)包括生物藥表征檢測（蛋白、多肽）、臨床前DMPK研究及生物分析。生物藥又稱為大分子藥，生物制品主要分為生物藥物和預防性生物藥物。預防性生物藥物主要指疫苗。生物藥物主要包括單克隆抗體、酶、干擾素、細胞因子和胰島素等。生物藥表征檢測服務(wù)在蛋白研究中，指的是蛋白質(zhì)的各項特性，包括結(jié)構(gòu)、理化、活性等一系列內(nèi)容。準確的氨基酸序列、分子量、價態(tài)變化、糖基化、聚集水平以及氧化水平都是蛋白質(zhì)藥物表征的關(guān)鍵要素。具體服務(wù)項目如下1.純度、肽圖分析（HPLC）采用高效液相色譜法對蛋白多肽的純度和肽圖譜進行分析，從而實現(xiàn)對蛋白質(zhì)純度和酶解后肽段分布情況的測定，對于蛋白多肽類藥物的進一步研究具有重要意義。純度可用于工業(yè)蛋白多肽樣品雜質(zhì)與含量分析。江蘇大分子生物分析平臺熙寧生物創(chuàng)始人曾參與《中國藥典2015版》“生物樣品分析方法驗證指導原則”；</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇好的大分子生物分析平臺,大分子生物分析平臺" src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413936783863215/2779163.png"></div><p style="text-indent:25px">隨著人類基因組計劃的完成，人們意識到基因的數(shù)量遠遠無法解釋生命的復雜性和多樣性。作為生命活動的基本元件，蛋白質(zhì)、核酸、糖脂等生物大分子的動態(tài)化學修飾成為生命多樣性和復雜性的物質(zhì)基礎(chǔ)，貫穿了細胞命運決定、性狀調(diào)控以及個體發(fā)育等一系列重要的生命活動。對生物大分子動態(tài)修飾的研究與調(diào)控逐漸成為當前生命科學領(lǐng)域受關(guān)注的領(lǐng)域之一，也成為化學與生命科學以及醫(yī)學交叉界面為活躍的研究前沿。國家自然科學基金會于2017年啟動了“生物大分子動態(tài)修飾與化學干預”重大研究計劃，旨在推動我國在該領(lǐng)域的發(fā)展，促進人們對生物大分子動態(tài)修飾機制的認識和對其功能的調(diào)控干預。近日，該重大研究計劃的**組和秘書組在ScienceChinaLifeSciences（《中國科學：生命科學》英文版）發(fā)表了題為“DynamicModificationsofBiomacromolecules:MechanismandChemicalInterventions”的文章，系統(tǒng)介紹了該重大研究計劃的科學意義、研究部署和項目啟動后取得的突出進展。文章首先介紹了生物大分子動態(tài)修飾研究的背景與現(xiàn)狀，闡明深入研究生物大分子動態(tài)修飾的機制和功能是揭示新的生命過程、發(fā)現(xiàn)新的疾病診療手段的重要基礎(chǔ)，有著深遠的科學意義和社會價值。</p><p style="text-indent:25px">人體中甲狀腺分泌較主要的是血清三碘甲狀腺素(T3)、甲狀腺素(T4)和促甲狀腺素(TSH)，這些對人體的生長發(fā)育具有重要作用。其中，T3、T4兩種包含與特定蛋白結(jié)合的和游離的（FT3、FT4）兩種。血的T3、T4中有99%以上與蛋白結(jié)合，進入細胞發(fā)揮作用的游離只有不到總的1%。根據(jù)不同檢測項目的醫(yī)學要求，常會檢測TSH、總T3、T4（蛋白結(jié)合的與游離之和）、游離的FT3、FT4。臨床意義1．總?cè)饧紫僭彼幔═T3)TT3是甲狀腺對各種靶作用的主要。血清TT3濃度反映甲狀腺對周邊組織的功能優(yōu)于反映甲狀腺分泌狀態(tài)。TT3是查明早期甲亢、監(jiān)控復發(fā)性甲亢的重要指標。TT3測定也可用于T3型甲亢的查明和假性甲狀腺毒癥的診斷。增高：甲亢，高TBG血癥，醫(yī)源性甲亢，甲亢中及甲減早期TT3呈相對性增高；碘缺乏性甲狀腺腫病人的TT4可降低，但TT3正常，亦呈相對性升高；T3型甲亢，部分甲亢患者TT4濃度正常，TSH降低，TT3明顯增高。降低：甲減，低T3綜合征（見于各種嚴重，慢性心、腎、肝、肺功能衰竭，慢性消耗性疾病等），低TBG血癥等。2．總甲狀腺素（TT4）TT4是甲狀腺分泌的主要產(chǎn)物，也是構(gòu)成下丘腦-垂體前葉-甲狀腺調(diào)節(jié)系統(tǒng)完整性不可缺少的成份。胞內(nèi)細胞因子流式分析法是用抗細胞因子抗體與細胞表面或胞內(nèi)特定亞群標志物組合。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇好的大分子生物分析平臺,大分子生物分析平臺" src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413936681030892/5849960.png"></div><p style="text-indent:25px">什么是CCRP?CCRP(犬C反應蛋白）通過肝臟合成，參與機體免疫反應，臨床上犬**常用的急性時相反映指標概念描述，組織損傷，惡性刺激產(chǎn)生?參與機體免疫反應?康復后恢復正常半衰期5—7hr?早期判斷具有很強敏感性CCRP判斷炎癥程度輔助鑒別疾病類型細菌CRP表現(xiàn)：提供比WBC、SAA更精確的信息，子宮蓄膿升高20倍CRP表現(xiàn)：細小CRP升高10及以上血液寄生蟲CRP表現(xiàn)：心絲蟲動脈內(nèi)膜炎和動脈高壓CRP明顯升高5倍，犬巴貝斯蟲CRP升高30倍以上，靈敏度高于白細胞創(chuàng)傷性疾病CRP表現(xiàn)：創(chuàng)傷性疾病手術(shù)后CRP濃度明顯升高疾病CRP表現(xiàn)：乳腺患犬明顯升高2倍，淋巴、急性淋巴細胞白血病、慢性淋巴細胞白血病明顯身高5至10倍CRP檢測方法比較單向免疫擴散法優(yōu)點：特異性高，重復性好，操作簡單，價格低廉，不需要特殊儀器檢測等優(yōu)點缺點：易出現(xiàn)假陰性，需稀釋重檢，敏感性差乳膠免疫比濁法優(yōu)點：操作簡單、快速，敏感性、特異性較高缺點：產(chǎn)生假陽性結(jié)果免疫層析法優(yōu)點：操作簡便、快捷缺點：靈敏度差化學發(fā)光法優(yōu)點：靈敏度高，特異性強，線性范圍寬，標記物穩(wěn)定，有效期長缺點：成本高，抗干擾性差，熙寧生物專注于大分子生物分析。在生物標志物的檢測上，MSD配套的試劑盒種類多樣，靈敏度高可進行各類細胞因子和趨化因子的定量檢測分析。江蘇大分子生物分析平臺</p><p style="text-indent:25px">血樣本凍存進行受體占位分析的試驗方案，可以讓所有臨床受試者的樣品均得到分析，熙寧生物專注于樣品分析。江蘇好的大分子生物分析平臺</p><p style="text-indent:25px">從而使流式細胞儀的檢測對象擴展到分子范圍。該領(lǐng)域的公司熙寧生物專注于大分子生物檢測分析。2.從相對計數(shù)到實際計數(shù)傳統(tǒng)流式細胞儀測試結(jié)果為相對計數(shù)，即目標細胞在某一總體系中的比值。隨著應用的深入，證明更具實際價值。目前主要采用計數(shù)微球和測定進樣體積來實現(xiàn)。3.流路、光路、數(shù)據(jù)分析的優(yōu)化速度的提升是光路，流路和數(shù)據(jù)采集系統(tǒng)三者共同優(yōu)化改善的結(jié)果。流路：Guava平臺easyCyte(現(xiàn)被Luminex公司收購)通過負壓進樣，其優(yōu)點是無需鞘液，產(chǎn)生廢液也少；Thermo公司聲波流式細胞儀AttuneNxT利用超聲波將細胞聚集在樣品流中軸線上，加快了進樣速度；光路：龐大的水冷或氣冷的激光器逐漸被小型化的固態(tài)激光器取代、光纖傳導應用越來越普遍、雪崩光電二極管等等新檢測器提供新的選擇；√數(shù)據(jù)分析：隨著數(shù)字化技術(shù)的引入以及數(shù)據(jù)處理系統(tǒng)的升級，流式細胞儀的數(shù)據(jù)處理能力得到極大提升。4.從傳統(tǒng)流式到質(zhì)譜流式&光譜流式傳統(tǒng)流式存在光譜滲漏、自發(fā)熒光等問題，使用的熒光染料的數(shù)量越多，這些問題就越大，為了克服這些問題，出現(xiàn)了質(zhì)譜流式和光譜流式。質(zhì)譜流式：與傳統(tǒng)流式相比，其標簽系統(tǒng)（金屬元素）和檢測系統(tǒng)（ICP質(zhì)譜技術(shù)）不同。江蘇好的大分子生物分析平臺</p><p style="text-indent:25px">寧波熙寧檢測技術(shù)有限公司主營品牌有熙寧，發(fā)展規(guī)模團隊不斷壯大，該公司服務(wù)型的公司。公司是一家有限責任公司（自然）企業(yè)，以誠信務(wù)實的創(chuàng)業(yè)精神、專業(yè)的管理團隊、踏實的職工隊伍，努力為廣大用戶提供***的產(chǎn)品。公司擁有專業(yè)的技術(shù)團隊，具有生物分析，臨床檢測，生物藥檢測，免疫原性檢測等多項業(yè)務(wù)。寧波熙寧檢測技術(shù)自成立以來，一直堅持走正規(guī)化、專業(yè)化路線，得到了廣大客戶及社會各界的普遍認可與大力支持。</p></p><br /><p>文章來源地址: http://m.cdcfah.com/cp/2811247.html</p></div></div></div></div></div><div id="ys3aypr" class="page-right twoColRt"><div id="3h8hpw2" class="box01 margin10 clearfix"><h3><a href="http://m.cdcfah.com/cp/">猜你喜歡</a></h3><div id="cw3rya2" class="recomPic likePro"><a href="http://m.cdcfah.com/cp/814588.html"><div><img src="http://tyunfile.71360.com/UpLoadFile/2019/11/1/14/637082168864691056_lgpj_5374157.jpg" alt="福建ZF配件哪家強信息推薦自業(yè)物資供應" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></div><p>福建ZF配件哪家強信息推薦自業(yè)物資供應</p></a></div><div id="bvsf87e" class="recomPic likePro"><a href="http://m.cdcfah.com/cp/846569.html"><div><img 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