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id="88zbyqx" class="proBig"><div id="8f7q7hr" class="bigimg"><div><p class="pic"><img src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413990103656258/2122084.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="vebd8q2" class="smallimg"><div><p class="pic"><img src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413990103656258/2122084.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="mfcuyu3" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>江蘇精翰生物結(jié)合,精翰生物</p><p><span>***更新：</span>2021-01-08 06:08:39</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="2tiz32d" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">寧波熙寧檢測技術(shù)有限公司</a></p><p><span>聯(lián)系人：</span>王蒙</p><p><span>郵箱: </span>meng.wang@accurantbio.com</p><p><span>電話: </span>13585708897</p><p><span>傳真: </span>0574_</p><p><span>網(wǎng)址: </span>https://www.accurantbio.com</p><p><span>手機(jī): </span>0574-87878487</p><p><span>地址: </span>浙江省寧波市鄞州區(qū)聚賢路587弄A5幢4樓</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="voli9qu" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="hro3tah" class="box"><p><p style="text-indent:25px"> 近十年，在研和上市的生物藥物從規(guī)模來看快速增長，從類型來講成多樣化的趨勢。生物藥物包括單克隆抗體，雙/多特異抗體，抗體偶聯(lián)藥物，重組蛋白和多肽，以延長半衰期經(jīng)過PEG，江蘇精翰生物結(jié)合，抗體Fc端或者人血清白蛋白修飾融合的重組蛋白和多肽，江蘇精翰生物結(jié)合，以介導(dǎo)進(jìn)入細(xì)胞膜經(jīng)過環(huán)肽修飾的重組蛋白等。相對于傳統(tǒng)的單一功能的單抗類和重組蛋白類生物藥物，以雙特異抗體藥物為的多功能域的生物類藥物的藥代動(dòng)力學(xué)表征面臨特別的挑戰(zhàn)。多功能域的生物藥物意味著在評估其生物轉(zhuǎn)換或者抗藥抗體干擾時(shí)，需要考慮每一個(gè)功能域的影響，江蘇精翰生物結(jié)合。藥代動(dòng)力學(xué)評估在整個(gè)藥物研發(fā)的進(jìn)程中是必不可少和尤為重要的，藥物的藥代動(dòng)力學(xué)評估依賴生物學(xué)分析方法，多個(gè)功能域的雙特異抗體藥物意味著可能需要多個(gè)生物學(xué)分析方法。血樣本凍存進(jìn)行受體占位分析的試驗(yàn)方案，可以讓所有臨床受試者的樣品均得到分析，熙寧生物專注于樣品分析。江蘇精翰生物結(jié)合</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇精翰生物結(jié)合,精翰生物" src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413990103656258/2122084.png"></div><p style="text-indent:25px">為了滿足臨床大批量樣品的測定需求，涉及抗原、抗體的特異性結(jié)合，這就不可避免地存在交叉反應(yīng)等非特異性問題。國際醫(yī)學(xué)溯源性參考檢測方法國際溯源性參考方法—質(zhì)譜檢測法國際檢驗(yàn)醫(yī)學(xué)溯源聯(lián)合會(huì)（JCLTM）的主要任務(wù)是通過實(shí)施參考系統(tǒng)，建立檢驗(yàn)結(jié)果溯源性，改進(jìn)其可比性，從而提高醫(yī)療衛(wèi)生質(zhì)量并降低費(fèi)用。JCTLM設(shè)立工作框架，按照國際標(biāo)準(zhǔn)(ISO17511，15193，15194)建立參考物質(zhì)和參考測量程序認(rèn)定步驟。在JCTLM官網(wǎng)上查到檢測TT3、TT4和FT4的溯源性參考方法均為應(yīng)用質(zhì)譜法檢測。本文挑選三篇年份較近的溯源性參考方法的信息進(jìn)行簡單介紹：TT3溯源性液質(zhì)參考方法信息(來自美國國家標(biāo)準(zhǔn)與技術(shù)研究院，NIST)，TT4溯源性液質(zhì)參考方法信息（來自英國化學(xué)家實(shí)驗(yàn)室，LGC）FT4溯源性液質(zhì)參考方法信息（來自比利時(shí)根特大學(xué)，GhentUniversity）國內(nèi)候選參考方法（質(zhì)譜法）推薦本方法為原國家衛(wèi)生部臨床檢驗(yàn)中心在2015年發(fā)布的TT4檢測的候選參考方法。江蘇精翰生物結(jié)合Blinatumomab的藥代動(dòng)力學(xué)分析方法不同于以配體受體結(jié)合實(shí)驗(yàn)為平臺(tái)的傳統(tǒng)生物分析方法，依據(jù)細(xì)胞平臺(tái)建立。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇精翰生物結(jié)合,精翰生物" src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413989888138228/1665787.png"></div><p> 商業(yè)化試劑盒為生物標(biāo)志物提供了一種操作簡易、移植性強(qiáng)、高效便捷的快速檢測方案。相比較開發(fā)一個(gè)全新的方法用于生物標(biāo)志物的檢測，直接使用商業(yè)化的試劑盒可以地縮短生物分析方法建立的時(shí)間，減少方法建立所需的資源。目前商業(yè)化試劑盒的生產(chǎn)商也往往會(huì)基于用戶的需求對其產(chǎn)品進(jìn)行開發(fā)分類，。 </p> <p> <span style="display:none;"></span>使用商業(yè)化試劑盒也會(huì)遇到一些限制。從產(chǎn)品設(shè)計(jì)上來說，商業(yè)化試劑盒并不是為了某個(gè)特定的臨床項(xiàng)目而進(jìn)行設(shè)計(jì)的，因此對于一個(gè)特定的臨床項(xiàng)目來說，使用商業(yè)化試劑盒是否合適或者說選擇哪個(gè)商業(yè)化的試劑盒就需要進(jìn)行額外的評估。從開發(fā)程度上來說，雖然商業(yè)化試劑盒在研發(fā)過程中有內(nèi)部的考察項(xiàng)和合格標(biāo)準(zhǔn)，但不同的生產(chǎn)商對試劑盒的標(biāo)準(zhǔn)相差甚遠(yuǎn)，不同供應(yīng)商的產(chǎn)品在穩(wěn)定性和重現(xiàn)性上也差別較大，在實(shí)際的生物分析方法中需要進(jìn)行確認(rèn)。從分析方法驗(yàn)證的角度上來說，需要對分析方法進(jìn)行特定的驗(yàn)證項(xiàng)的考察，這些驗(yàn)證通常是試劑盒生產(chǎn)商并未在產(chǎn)品開發(fā)中進(jìn)行過的。所以總的來說，不管選用哪個(gè)廠家的何種試劑盒，在進(jìn)行生物樣本檢測之前，都需要進(jìn)行進(jìn)一步的方法參數(shù)確認(rèn)和調(diào)整。 </p><p>利用三重四級桿質(zhì)譜進(jìn)行SRM掃描是目前質(zhì)譜臨床檢測的金標(biāo)準(zhǔn)，但I(xiàn)GF-1的三對二硫鍵非?？拷陨淼腘端和C端，因此難以碎裂產(chǎn)生特異性高的碎片離子來對該分子進(jìn)行定量。從2011年開始，美國的大型第三方**醫(yī)學(xué)實(shí)驗(yàn)室就開始探討利用**辨質(zhì)譜定量類胰島素生長因子1的可能性,并在長期的臨床實(shí)踐中證明了其的可靠性。在線SPE結(jié)合Orbitrap是檢測IGF-1的*****為了阻斷IGFBP3對IGF1檢測的干擾，在樣品前處理時(shí)我們需要采用經(jīng)典的酸性乙醇沉淀法來阻斷IGFBP3和IGF1的結(jié)合[4]。隨后需要進(jìn)行SPE來去除鹽以及其他一些干擾檢測的雜質(zhì)。但是采用常規(guī)的離線SPE的話會(huì)導(dǎo)致IGF-1的發(fā)生不可忽略的氧化，可能是由于在離線SPE時(shí)，柱床的干涸催化了IGF-1甲硫氨酸的氧化。因此我們采用在線SPE的方法來進(jìn)行樣品的凈化。Vanquish超高效液相色譜具有強(qiáng)大的靈活性，模塊的任意搭配可實(shí)現(xiàn)所有的色譜工作模式。對于肽段或者蛋白質(zhì)類被分析物，液相系統(tǒng)的生物兼容性是一個(gè)必須考察的問題，不然可能影響色譜峰型和殘留效應(yīng)。ThermoFisher的nanoViper?管線提供了杰出的生物兼容性，并且跟**經(jīng)常使用的PEEK材質(zhì)管線相比，nanoViper?管線耐壓1200bar,和超高效液相色譜無縫兼容。從穩(wěn)轉(zhuǎn)細(xì)胞株構(gòu)建，方法開發(fā)優(yōu)化，到方法驗(yàn)證和樣本分析，熙寧提供一體化全流程細(xì)胞學(xué)生物分析方法服務(wù)。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇精翰生物結(jié)合,精翰生物" src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413990222913633/9496123.png"></div><p style="text-indent:25px">染色體分析染色體分析直接檢測染色體數(shù)目及結(jié)構(gòu)的異常，而不是檢查某條染色體上某個(gè)基因的突變或異常。通常用來診斷胎兒的異常。常見的染色體異常是多一條染色體，檢測用的細(xì)胞來自血液樣本，若是胎兒，則通過羊膜穿刺或絨毛膜絨毛取樣獲得細(xì)胞。將之染色，讓染色體凸顯出來，然后用高倍顯微鏡觀察是否有異常。DNA分析主要用于識(shí)刖單個(gè)基因異常引發(fā)的遺傳性疾病，如亨廷頓病等。DNA分析的細(xì)胞來自血液或胎兒細(xì)胞?；驒z測的分類基因檢測可以分為：基因篩檢主要是針對特定團(tuán)體或全體人群進(jìn)行檢測。大多數(shù)通過產(chǎn)前或新生兒的基因檢測以達(dá)到篩檢的目的。生殖性基因檢測在進(jìn)行體外人工授精階段可運(yùn)用，篩檢出胚胎是否帶有基因變異，避免胎兒患有遺傳性疾病。診斷性檢測多數(shù)用來協(xié)助臨床用藥指導(dǎo)。基因攜帶檢測基因攜帶者如果與某些特殊基因相結(jié)合，可能會(huì)導(dǎo)致下一代患基因疾病，通過基因攜帶者的檢測可篩檢出此種可能，作為基因攜帶者婚前檢查、生育時(shí)的參考。癥狀出現(xiàn)前的檢測檢測目的是了解目前健康良好者是否帶有某種突變基因，而此基因與特定疾病的發(fā)生有密切的聯(lián)系?；驒z測的臨床意義是用于疾病的診斷?？梢栽谕粋€(gè)細(xì)胞內(nèi)同時(shí)檢測兩種或更多種細(xì)胞因子，也可根據(jù)細(xì)胞免疫表型區(qū)分細(xì)胞的亞型。江蘇精翰生物結(jié)合</p><p style="text-indent:25px">中和抗體檢測方法中具備很好的適應(yīng)性，熙寧生物具有自主知識(shí)產(chǎn)權(quán)。江蘇精翰生物結(jié)合</p><p>ThermoFisher的TranscendII系列多通道液相就是為這種需求量身定制的。得益于TranscendII系統(tǒng)的AriaOS智能化控制軟件，使用者不需要考慮通道之間的復(fù)雜閥切換,只需設(shè)置色譜梯度和質(zhì)譜采集的時(shí)間窗口，軟件即會(huì)自動(dòng)優(yōu)化通道切換，從而實(shí)現(xiàn)**多四通道的同時(shí)檢測（圖4B）。針對于IGF-1這個(gè)例子，我們在線SPE的色譜梯度為5分鐘，但實(shí)際上目標(biāo)和內(nèi)標(biāo)化合物出峰的時(shí)間窗口不足20秒（圖4A），因此我們在Aria軟件中將質(zhì)譜的采集窗口設(shè)置為–，這樣平均下來每個(gè)樣品的檢測時(shí)間即為，這不僅極大的提升了通量，也將質(zhì)譜的利用率提升了4倍，極大的節(jié)約了成本。圖（點(diǎn)擊查看大圖）對于IGF-1的檢測，我們需要進(jìn)行在線SPE，因此我們可以選擇TranscendIITLX-4這套四通道在線前處理液相來進(jìn)行。這套系統(tǒng)配備4臺(tái)上樣泵，4臺(tái)洗脫泵，1臺(tái)CTC雙臂自動(dòng)進(jìn)樣器和一個(gè)閥箱（圖5）。圖（圖6），從而使得高通量，低成本和減少樣本處理時(shí)間得以并存。圖（點(diǎn)擊查看大圖）結(jié)論Orbitrap不僅是蛋白質(zhì)組學(xué)研究的*****，也在臨床檢測應(yīng)用領(lǐng)域體現(xiàn)出極大的優(yōu)勢。結(jié)合ThermoFisherTranscendII多通道液相系統(tǒng)，可極大的提升實(shí)驗(yàn)室產(chǎn)能并降低成本。此外TranscendII系統(tǒng)**的TurboFlow?。江蘇精翰生物結(jié)合</p><p style="text-indent:25px">寧波熙寧檢測技術(shù)有限公司是一家一般項(xiàng)目：技術(shù)服務(wù)、技術(shù)開發(fā)、技術(shù)咨詢、技術(shù)交流、技術(shù)轉(zhuǎn)讓、技術(shù)推廣；醫(yī)學(xué)研究和試驗(yàn)發(fā)展；實(shí)驗(yàn)分析儀器銷售；儀器儀表銷售（除依法須經(jīng)批準(zhǔn)的項(xiàng)目外，憑營業(yè)執(zhí)照依法自主開展經(jīng)營活動(dòng)）。許可項(xiàng)目：貨物進(jìn)出口，技術(shù)進(jìn)出口，進(jìn)出口代理（依法須經(jīng)批準(zhǔn)的項(xiàng)目，經(jīng)相關(guān)部門批準(zhǔn)后方可開展經(jīng)營活動(dòng)，具體經(jīng)營項(xiàng)目以審批結(jié)果為準(zhǔn)）。的公司，是一家集研發(fā)、設(shè)計(jì)、生產(chǎn)和銷售為一體的專業(yè)化公司。寧波熙寧檢測技術(shù)擁有一支經(jīng)驗(yàn)豐富、技術(shù)創(chuàng)新的專業(yè)研發(fā)團(tuán)隊(duì)，以高度的專注和執(zhí)著為客戶提供生物分析，臨床檢測，生物藥檢測，免疫原性檢測。寧波熙寧檢測技術(shù)繼續(xù)堅(jiān)定不移地走高質(zhì)量發(fā)展道路，既要實(shí)現(xiàn)基本面穩(wěn)定增長，又要聚焦關(guān)鍵領(lǐng)域，實(shí)現(xiàn)轉(zhuǎn)型再突破。寧波熙寧檢測技術(shù)始終關(guān)注自身，在風(fēng)云變化的時(shí)代，對自身的建設(shè)毫不懈怠，高度的專注與執(zhí)著使寧波熙寧檢測技術(shù)在行業(yè)的從容而自信。</p></p><br /><p>文章來源地址: http://m.cdcfah.com/cp/2753767.html</p></div></div></div></div></div><div id="f2pbaho" class="page-right twoColRt"><div id="scu93g8" class="box01 margin10 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