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class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>山東高質(zhì)量煙酰胺單核苷酸,煙酰胺單核苷酸</p><p><span>***更新：</span>2020-12-23 07:14:58</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="ijdpd7u" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海北倉化工科技有限公司</a></p><p><span>聯(lián)系人：</span>王金良</p><p><span>郵箱: </span>shbeicang@vip.126.com</p><p><span>電話: </span>18516286991</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span>http://www.shbeicang.cn</p><p><span>手機(jī): </span>021-60459206</p><p><span>地址: </span>金山大道4168號</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="bggoh12" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="1im0p4v" class="box"><p><p style="text-indent:25px">β-煙酰胺單核苷酸如何購買 : 在您確定購買后，請將您的詳細(xì)需求一并告知我們的銷售人員，包括產(chǎn)品名稱，數(shù)量，包裝要求等，山東高質(zhì)量煙酰胺單核苷酸，并一并通知我們您的收貨地址，發(fā)票單位名稱，山東高質(zhì)量煙酰胺單核苷酸，聯(lián)系方式；然后由我們銷售人員為您做一份訂單，山東高質(zhì)量煙酰胺單核苷酸，您確認(rèn)無誤后，請按照我們提供的匯款信息安排貨款，待貨款確認(rèn)后我們立即將貨物發(fā)出 ?作為一家新興企業(yè)，一直把質(zhì)量視為企業(yè)的生命，尤其是我們原料藥行業(yè)，我們的一個(gè)小小的質(zhì)量失誤可能會給客戶造成巨大的甚至不可逆的損失。所以質(zhì)量保證尤為重要。傳統(tǒng)的β-煙酰胺單核苷酸生產(chǎn)方法是以煙酰胺核糖為原料。山東高質(zhì)量煙酰胺單核苷酸</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="山東高質(zhì)量煙酰胺單核苷酸,煙酰胺單核苷酸" src="https://tyunfile.71360.com/UploadFile/shbeicanghuagong/637326786594501953/9357235.png"></div><p style="text-indent:25px">衰老過程中NAD+的下降被認(rèn)為是導(dǎo)致疾病和殘疾的主要原因，如聽力和視力喪失，認(rèn)知和運(yùn)動功能障礙，免疫缺陷，自身免疫炎癥反應(yīng)失調(diào)導(dǎo)致的關(guān)節(jié)炎、代謝障礙和心血管疾病。因此，補(bǔ)充NMN提高了體內(nèi)NAD+含量，從而延緩、改善、防止衰老相關(guān)的多種表型，或年齡誘導(dǎo)的代謝紊亂、老年疾病等。NAD+依賴的脫乙酰酶SIRT1通過連接調(diào)節(jié)NAD+補(bǔ)救途徑的酶反饋回路和晝夜節(jié)律轉(zhuǎn)錄-翻譯反饋回路，成為晝夜節(jié)律與代謝之間的橋梁。NAD+調(diào)節(jié)生物鐘是通過SIRT1實(shí)現(xiàn)的。SIRT1將BMAL1和PER2去乙?；?，而這和CLOCK的乙?；δ苁寝卓沟?，所以SIRT1能阻抑CLOCK- BMAL1介導(dǎo)的clock genes的轉(zhuǎn)錄。因此，NAD+通過自身水平影響SIRT1去乙酰化活性，從而反過來影響包括NAMPT在內(nèi)的一系列生物鐘相關(guān)蛋白的表達(dá)。山東高質(zhì)量煙酰胺單核苷酸β-煙酰胺單核苷酸在人類細(xì)胞能量的產(chǎn)生中起著重要作用。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="山東高質(zhì)量煙酰胺單核苷酸,煙酰胺單核苷酸" src="https://tyunfile.71360.com/UploadFile/shbeicanghuagong/637326786844257812/7332830.png"></div><p style="text-indent:25px">NMN (β-煙酰胺單核苷酸)是煙酰胺磷酸核糖轉(zhuǎn)移酶反應(yīng)的產(chǎn)物, 是NAD+的關(guān)鍵前體之一。在哺乳動物體內(nèi), NMN由煙酰胺在Nampt的催化下生成, 隨后NMN在煙酰胺單核苷酸腺苷轉(zhuǎn)移酶的催化下生成NAD+。細(xì)胞外NMN需要去磷酸轉(zhuǎn)化為煙酰胺核苷，才能進(jìn)入肝細(xì)胞內(nèi)部。進(jìn)入胞內(nèi)后, NR在煙酰胺核苷激酶1 的作用下磷酸化生成NMN, 隨后NMN和ATP結(jié)合生成NAD。NMN在人體內(nèi)可以轉(zhuǎn)化為NAD+, 如活躍NAD+底物依賴性酶Sirt1 (組蛋白脫乙酰酶, 又稱沉默調(diào)節(jié)蛋白) 、調(diào)節(jié)細(xì)胞存活和死亡、維持氧化還原狀態(tài)等。</p><p style="text-indent:25px">β-煙酰胺單核苷酸簡稱NMN，為煙酸的衍生物，是一種天然存在于食物和人體中的維生素B3代謝物。煙酰胺單核苷酸是一種核苷酸，是煙酰胺腺嘌呤二核苷酸(NAD+)的前體。NAD+是一種在體內(nèi)具有多種功能的分子，主要通過促進(jìn)一種叫做sirtuins的細(xì)胞信號酶發(fā)揮作用。這些酶對人體正常功能至關(guān)重要，尤其是SIRT1(有7種sirtuins)。研究表明，它在熱量限制后非?；钴S，這本身就帶來了多種好處，包括延長壽命的跡象。可以肯定的是，進(jìn)一步的測試揭示，SIRT1水平升高可以保護(hù)代謝下降和疾病。β-煙酰胺單核苷酸酶促反應(yīng)常常涉及到多種瓶頸，如酶法高昂的成本，反應(yīng)條件苛刻，生產(chǎn)工藝不穩(wěn)定。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="山東高質(zhì)量煙酰胺單核苷酸,煙酰胺單核苷酸" src="https://tyunfile.71360.com/UploadFile/shbeicanghuagong/637326786247109375/889767.png"></div><p style="text-indent:25px">本實(shí)用新型的目的在于克服現(xiàn)有技術(shù)中的缺陷,提供一種β- 煙酰胺單核苷酸生產(chǎn)工藝中的廢氣集中處理裝置,其工作效率高,能有效去除有機(jī)廢氣,并吸收酸性廢氣和氨。為實(shí)現(xiàn)上述目的,本實(shí)用新型采用如下技術(shù)方案:一種β-煙酰胺單核苷酸生產(chǎn)工藝中的廢氣集中處理裝置,包括廢氣總管、水洗塔、酸洗塔、水循環(huán)泵、酸循環(huán)泵、風(fēng)機(jī)和廢氣排放管,所述水洗塔和酸洗塔之間連接一級廢氣管,所述酸洗塔和風(fēng)機(jī)之間連接二級廢氣管,所述一級廢氣管上設(shè)置一級廢氣檢測裝置,所述二級廢氣管上設(shè)置二級廢氣檢測裝置,所述一級廢氣管與二級廢氣管之間連有旁通管，所述旁通管上設(shè)置閥門,所述一級廢氣管在所述旁通管的開口之后設(shè)置閥門。煙酰胺單核苷酸是煙酰胺磷酸核糖轉(zhuǎn)移酶(Nampt)反應(yīng)的產(chǎn)物，是NAD+的關(guān)鍵前體之一。山東高質(zhì)量煙酰胺單核苷酸</p><p style="text-indent:25px">β-煙酰胺單核苷酸/NMN在動物模型中被證實(shí)可以延長小鼠壽命多達(dá)30%。山東高質(zhì)量煙酰胺單核苷酸</p><p style="text-indent:25px">β-煙酰胺單核苷酸純化過程:將濃縮后的粗品溶液用磷酸溶液或鹽酸溶液調(diào)pH至3-7 ,將色譜柱用30%以上的乙醇沖洗干凈后平衡上樣，上樣量為350-400g。線性梯度洗脫40min ,收集目的峰。濃縮及凍干:將純化后的樣品溶液用膜濃縮設(shè)備(截留分子量200的中空纖維膜)納濾濃縮至100-150g/L ,然后用真空冷凍干燥機(jī)凍干,得到純度大于98%的β -煙酰胺單核苷酸,總收率可以達(dá)到80.9%。通過收集樣品的目的峰，當(dāng)其達(dá)到標(biāo)準(zhǔn)時(shí),則將其用膜濃縮設(shè)備進(jìn)行納濾,再用真空冷凍干燥機(jī)凍干,獲得純化的煙酰胺單核苷酸。由本發(fā)明所述方法制備的凍干產(chǎn)品煙酰胺單核苷酸,其純度可達(dá)98% 。山東高質(zhì)量煙酰胺單核苷酸</p></p><br /><p>文章來源地址: 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