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#f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>天津Claudin18.2蛋白產(chǎn)品介紹,Claudin18.2蛋白</p><p><span>***更新：</span>2020-09-07 03:05:38</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="tq3lhyf" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機: </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號昂立大廈2113室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="jhoktua" class="page-proshow02"><p class="title">詳細說明</p><div id="or27tmx" class="box"><p><p style="text-indent:25px">Claudin是細胞粘合蛋白之一，有20幾個家族成員，不同組織、不同亞型的Claudin除粘合細胞外還有其它功能。Claudin18.2*在胃上皮細胞短暫表達，其它正常組織幾乎沒有表達。但是很多組織*變后Claudin18.2表達會異常升高，目前這個蛋白在**發(fā)生、轉(zhuǎn)移中的作用尚不清楚，似乎與細胞粘合關(guān)系不大。簡單從細胞粘合機理看阻斷Claudin似乎會打碎細胞聯(lián)合、加速**轉(zhuǎn)移，也確實有研究顯示阻斷某些Claudin會加速**轉(zhuǎn)移。但是因為Claudin18.2只在**細胞表達，所以可以比較安全地用抗體誘導(dǎo)細胞殺傷，天津Claudin18，天津Claudin18.2蛋白產(chǎn)品介紹.2蛋白產(chǎn)品介紹，天津Claudin18.2蛋白產(chǎn)品介紹。這和CD19、CD20抗體的思路類似，只是實體瘤特異的表面蛋白很少。這個靶點很多細節(jié)還需進一步研究。天津Claudin18.2蛋白產(chǎn)品介紹</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="天津Claudin18.2蛋白產(chǎn)品介紹,Claudin18.2蛋白" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969947460937/5782493.png"></div><p> 此次未提交）。主要研究終點是PFS（組1vs組2，70%效能，HR，單側(cè)P=）。結(jié)果：730例患者同意試驗，352例患者（48%）按照協(xié)議標(biāo)準(zhǔn)檢測CLDN。其中161例患者（中位年齡，58歲；64%為男性，80%是胃*，16%為EGJ；4%為食管*）被隨機分為組1和組2。該項研究達到它的終點。與單純EOX相比較，IMAB362聯(lián)合EOX提高了PFS（中位vs；HR；95%CI，單側(cè)P=）和OS（中位vs；HR；95%CI）。在CLDN（在≥70%的**細胞中≥2+強度），聯(lián)系更為***（PFS，vs；HR；OS，vs；HR）。最常見的IMAB362-相關(guān)的不良事件包括嘔吐，中性粒細胞減少和貧血，其中大多數(shù)為NCI-CT1/2級。3/4級事件在IMAB362中并未***增加。結(jié)論：IMAB362聯(lián)合**化療會帶來PFS和OS上的臨床相關(guān)獲益，存在良好風(fēng)險/獲益屬性。會議專題》》》2016年ASCO年會專題報道原文摘要：FAST:Aninternational,multicenter,randomized,phaseIItrialofepirubicin,oxaliplatin,andcapecitabine(EOX)withorwithoutIMAB362,afirst-in-classantibody,asfirst-linetherapyinpatientswithadvancedgastricandgastroesophagealjunction(GEJ)adenocarcinoma.（AbstractLBA4001）Authors：Salah-EddinAl-Batran,，：OralAbstractSessionBackground:()(pts)。天津Claudin18.2蛋白產(chǎn)品介紹</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="天津Claudin18.2蛋白產(chǎn)品介紹,Claudin18.2蛋白" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969950644531/2813598.png"></div><p style="text-indent:25px">原發(fā)性胃腺*組織中存在Claudinl8.2的表達，極為重要的是其中56%的組織表達量達到60%以上。與上述研究結(jié)果一致的是腸型胃*中Claudinl8.2蛋白的表達下調(diào)，而彌散型胃*中Claudinl8.2蛋白的表達較高。但是，胰腺、食道、卵巢等組織在正常狀態(tài)下沒有Claudinl8.2蛋白表達，而相應(yīng)的**組織中可以大量表達Claudinl8.2蛋白。所以，Claudin18.2 蛋白可以作為臨床**診斷和zhiliao的耙位。但，目前尚未見以該蛋白為靶位研制的**疫苗。zhiliao性疫苗研究進展近年來，針對人類自身蛋白的單克隆抗體在zhiliao急、慢性疾病的過程中顯示出了良好的效果。</p><p> 研究人員收集了免疫***的類型、自體免疫疾病耀斑和/或其他免疫***相關(guān)不良事件的數(shù)據(jù)，并將不良事件進行了分類，輕微事件為1-2級，嚴(yán)重事件為3-4級，并記錄了糖皮質(zhì)***或免疫******（IS）的使用情況。研究隊列包括銀屑病或銀屑病關(guān)節(jié)炎患者(31例)、類風(fēng)濕關(guān)節(jié)炎患者(20例)、風(fēng)濕性多***和/或巨細胞動脈炎患者(7例)、系統(tǒng)性紅斑狼瘡患者(4例)、皮膚局限性紅斑狼瘡患者(3例)或炎癥性腸病患者(14例)。irAE在這112例患者中，79例(71%)患者產(chǎn)生了免疫毒性，53例(47%)發(fā)生耀斑,47例(42%)產(chǎn)生了自體免疫疾病無關(guān)的免疫相關(guān)不良事件，20例（18%）患者同時產(chǎn)生了免疫毒性和irAE。1例患者由于免疫毒性而死亡，24例患者因免疫毒性長久停用ICI。表1自身免疫疾病患者使用ICI的安全性近一半的自體免疫疾病耀斑使用糖皮質(zhì)******(24例)，6例患者使用常規(guī)合成的抗風(fēng)濕藥，3例患者使用了生物類抗風(fēng)濕藥。共有24例非起始自體免疫疾病的免疫相關(guān)不良事件患者接受了糖皮質(zhì)******，其中7例患者還接受了另外IS***，包括甲氨蝶呤（一種**壞死因子***劑）、靜脈注射免疫球蛋白。自體免疫疾病患者使用ICI較安全DiviCornec博士指出，總的來說，在自體免疫疾病患者中使用ICI***是相當(dāng)安全的。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="天津Claudin18.2蛋白產(chǎn)品介紹,Claudin18.2蛋白" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969976787109/5241411.png"></div><p> 但有可能對患者的一個或多個基因突變有效的靶向療法。3.確定一種可能對所檢測出的一個突變或一個通路有效的試驗療法。了解國內(nèi)基因檢測技術(shù)Foundation基因檢測與國內(nèi)基因檢測的差異一次檢測，為患者提供準(zhǔn)確的基因檢測分析，***的靶向***信息，準(zhǔn)確患者病情的臨床試驗匯總。避免無效基因檢測避免錯誤基因檢測避免遺漏重要靶向***信息避免遺漏重要臨床實驗信息查看國內(nèi)基因檢測F1CDx在乳腺*中的應(yīng)用更新F1CDx在肺*中的應(yīng)用更新基因檢測的步驟患者提供近期病歷資料及病理報告，6-8微米厚的組織切片10-15張(未染色)；1張同部位的染色切片；整理翻譯病例資料，提交并郵寄組織切片；收到資料及組織切片后15~20個工作日出具檢測報告；**醫(yī)生根據(jù)基因檢測報告和病情決定***方案**綜合基因檢測報告樣本根據(jù)***下一代測序檢測結(jié)果，列出了檢測到的基因組改變，并附有基因組改變的頻次、生物學(xué)意義及其對患者有何意義。根據(jù)您所患**的基因組特征，列出了經(jīng)FDA批準(zhǔn)，您所患**可能對其敏感或產(chǎn)生耐藥的***。根據(jù)您所患**的基因組特征，列出了您有資格參加的臨床試驗。此外，報告還提供了指南，告知醫(yī)生如何在公共數(shù)據(jù)庫中找到可能適合您的其他試驗。天津Claudin18.2蛋白產(chǎn)品介紹</p><p style="text-indent:25px">天津Claudin18.2蛋白產(chǎn)品介紹</p><p> oundationmedicine與ASCO合作TAPUR研究Foundation與施貴寶達成協(xié)議，利用Foundation全基因檢測信息幫助施貴寶臨床試驗指導(dǎo)用藥基因檢測與**的個性化*****多基因檢測國內(nèi)全基因檢測**全基因檢測常見問題***案例非小細胞肺*患者找到靶向藥，病灶幾乎完全消退！戲劇性案例，美國foundation基因檢測為***轉(zhuǎn)移性非小細胞肺*患者找到靶向藥，病灶幾乎完全消退！成功***BRAFV600E突變**狀甲狀腺*患者女，73歲，先前被診斷為早期乳腺*，后行乳房**切除術(shù)Foundation基因檢測成功***轉(zhuǎn)移性肺腺*患者哥倫比亞大學(xué)醫(yī)學(xué)中心紐約長老會醫(yī)院報道了一個年輕的foundation檢測出了－種新型的克唑替尼敏感的ALK重排43歲，男性患者，無吸煙史，有心包填塞．心包／胸腔產(chǎn)生為什么選擇**綜合基因檢測?檢測更多的基因異常堿基置換插入和缺失拷貝數(shù)變異重組更多的靶向*****綜合基因檢測能找出比“多基因熱點檢測”多出2倍以上的靶向***選擇。在完成的**綜合基因檢測中，大約有82%的結(jié)果可指導(dǎo)臨床決策，這意味著該結(jié)果有助于1.確定一種已獲批適用于患者**類型，并對所檢測出的一個或多個基因突變有效的靶向療法。2.確定一種已獲批適用于其他類型**。天津Claudin18.2蛋白產(chǎn)品介紹</p><p style="text-indent:25px">上海朝瑞生物科技有限公司位于上海市松江區(qū)廣富林路697號昂立大廈2113室。公司業(yè)務(wù)涵蓋科研技術(shù)服務(wù)，應(yīng)用技術(shù)服務(wù)，科研成果轉(zhuǎn)化，科學(xué)產(chǎn)品銷售等，價格合理，品質(zhì)有保證。公司從事化工多年，有著創(chuàng)新的設(shè)計、強大的技術(shù)，還有一批**的專業(yè)化的隊伍，確保為客戶提供良好的產(chǎn)品及服務(wù)。在社會各界的鼎力支持下，持續(xù)創(chuàng)新，不斷鑄造***服務(wù)體驗，為客戶成功提供堅實有力的支持。</p></p><br /><p>文章來源地址: 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